Colchicine bertindak dengan menghalang penghijrahan sel darah putih (neutrofil) ke kawasan yang terjejas. Ini ibarat menghentikan kemasukan pasukan bomba yang tidak diperlukan ke kawasan kebakaran kecil—keradangan akan berkurang, dan kesakitan beransur-ansur reda.
Sekiranya anda berisiko mengambil NSAID atau colchicine, atau kedua-dua ubat tidak berfungsi dengan berkesan, doktor anda mungkin memberi anda steroid untuk merawat gout anda.
Very first-line gout therapy focuses on cutting down agony and inflammation. Ideally, cure ought to begin within just 24 hrs of the start from the gout attack. Treatment method is stopped once the attack is more than, and symptoms have long gone away. It includes the subsequent:
Steroid ini bertindak dengan cepat mengurangkan keradangan dan mengurangkan gejala serangan akut gout. Namun, penggunaan steroid jangka panjang tidak disarankan kerana risiko kesan sampingan seperti osteoporosis dan penambahan berat badan.
Jika anda kerap mengalami gout, doktor mungkin mencadangkan ujian darah untuk memantau tahap asid urik.
Numerous drugs are effective for acute flare-ups. The efficiency of reduced-dose colchicine is comparable to that of higher-dose colchicine with much less sakit gout boleh urut adverse results. NSAIDs and glucocorticoids are as successful as colchicine.
• Titrating urate-reducing therapy to achieve a serum urate standard of 6 mg for each dL decreases flare-ups gout sakit kaki and boosts treatment adherence.
Change to a different agent in sufferers with heritage of cardiovascular disease or new cardiovascular celebration
Febuxostat adalah ubat yang lebih baru dan juga digunakan untuk menurunkan tahap asid urik. Ia mungkin lebih website sesuai untuk pesakit yang tidak dapat bertoleransi dengan allopurinol.
Jika anda boleh bertolak ansur dengan tekanan pek ais, terapi sejuk ini boleh memberikan kelegaan rasa sakit dengan mengurangkan keradangan dan isyarat sakit.
Medicines to prevent recurrences of gout both block the manufacture of uric acid or improve its removal. Examples incorporate:
Contains a low potential for abuse relative to These in plan 3. It's got a presently approved health care use in therapy in The us. Abuse may bring on limited Actual physical dependence or psychological dependence relative to Individuals in plan 3.
In people who establish gout their innate immune system is just Lively if they have hyperuricaemia.
Colcrys (colchicine) is best when begun at the first signs or symptoms of the gout flare. Colchicine might should be dosed decreased for those with Long-term kidney sickness (CKD) and those who acquire some medicines, which include statins.